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In integrated transcriptomic and single-nucleus RNA sequencing (snRNA-seq) analyses, necroptosis was identified as a highly enriched RCD pattern in DKD tubules, defining distinct patient subtypes that correlate closely with chronic inflammatory responses and macrophage infiltration (229)

When BMSCs experience ferroptosis, characterized by elevated ROS, lipid peroxidation, and iron accumulation, their function is compromised, which may contribute to the pathogenesis of associated diseases [8]

PMID 27427481

Stimulation of macrophages by lipopolysaccharide alters the phosphorylation state, conformation, and function of PU.1 via activation of casein kinase II

L.TaylorM