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The trial involving more than 3500 participants with type 2 diabetes and chronic kidney disease from 28 countries including Australia, the USA and China found a small weekly dose of semaglutide reduced the risk of major kidney events by 24 per cent
No adverse events have been reported to date
Alongside dramatic weight reduction, participants showed impressive improvements in metabolic markers, including significant reductions in blood glucose levels, HbA1c normalization, improved lipid profiles, and substantial reductions in systemic inflammation markers like C-reactive protein (CRP)
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Further, ACMSD expression was significantly increased in the presence of the GCKR TT risk variant which has increased NASH susceptibility providing an opportunity for precision medicine
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