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One year after discontinuation, average weight regain was small
Researchers believe much of this protective effect stems from the catechins' antioxidant and anti-inflammatory actions
Mice were allowed access to food and water ad libitum and were housed on a 12 hr light/dark cycle
The strongest approved injection, tirzepatide, produced up to about 21% weight loss in its pivotal SURMOUNT-1 trial, published in the New England Journal of Medicine alongside the broader semaglutide STEP program in 2021, which established injectable semaglutide at around 15%
Review 2026 (Springer Inflammopharmacology, DOI 10.1007/s10787-025-01882-z) confirmed its cytoprotective effect on the digestive tract with oral doses ranging from 10 to 50 g/kg
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