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When HFSCs receive Wnt signals, the -catenin signaling pathway is activated, causing HFSCs to switch from a quiescent state to a proliferative state, initiating the regeneration program (Hsu et al., 2011

Neurological manifestations are particularly concerning and may include peripheral neuropathy with paresthesias (tingling and numbness in hands and feet), ataxia, impaired proprioception and vibratory sense, cognitive impairment, memory loss, and in severe cases, subacute combined degeneration of the spinal cord

BPC-157 has a plasma half-life of less than 30 minutes and is rapidly metabolized

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