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The unfolded protein response (UPR) is triggered when an excessive amount of misfolded proteins accumulate in the ER, which can be caused by overnutrition, increased reactive oxygen species (ROS), or proinflammatory cytokines ( Figure 2A )
Second, even taken at face value, an assay-specific potency ratio is not a measure of whole-organism effect: it does not mean Dihexa is millions of times more effective in a living brain, where absorption, distribution, and signaling context all differ
Figure 3 2 presence and activation of PKC
Wild type SOD1 is a covalent disulfide-linked homodimer localized in part in the mitochondrial intermembrane space
