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Abraham, M
Triggered by upstream signals, the initiator caspases undergo autocleavage, and the subsequently activated cleaved initiator caspases stimulate the downstream executioner caspases to execute apoptosis (106)
Both enzymes, GPX7 and GPX8, are located in the endoplasmic reticulum and are necessary enzymes involved in the oxidative folding of endoplasmic reticulum proteins, and GPX8 also plays an important role in the regulation of Ca 2+ in the endoplasmic reticulum
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Impaired gut barrier function: Gluten or dairy sensitivity can lead to increased intestinal permeability or "leaky gut," which may impair the release of DAO into the intestinal lumen where it is needed to break down histamine
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