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In the retatrutide phase 2 trial at 48 weeks, the 12 mg group reported 100% of participants losing at least 5%, 93% losing at least 10%, and 83% losing at least 15% though this was a smaller, earlier-stage study
Both WT and V229A receptors existed predominantly as monomers or dimers at a proportion of 60 to 80% of total receptors, a percentage that was reduced for the WT receptor at later acquisition times under vehicle conditions, but with otherwise few changes following exendin-4 stimulation
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