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Analyses were performed using JMP v.17.0.0
It is also needed for healthy red blood cell formation and for the development and function of the central nervous system (brain, spinal cord, and nerves)
There has also been a suggestion it might help with cognitive performance, such as improved focus and concentration, but clinical trials are needed to confirm this
"Centenarians display plasma MOTS-c concentrations significantly higher than age-matched peers, a pattern that closely resembles levels found in individuals decades younger suggesting preserved mitochondrial signaling as a hallmark of exceptional longevity." The connection to cellular senescence deserves further attention here
The transendothelial electrical resistance (TEER) is a quantitative marker of BBB integrity and is evaluated by Ohm's law or impedance spectroscopy (DeStefano et al., in vivo as 5,000 ohm/cm 2 with physiological values that may be as low as 1,500 ohm/cm 2
