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High-performance liquid chromatography (HPLC) or mass spectrometry can detect degradation products, but these assays are impractical for routine verification in most research settings

PMID: 107 WangC.XieL.XingY.LiuM.YangJ.GaoN.et al

Hydrochloric acid and/or sodium hydroxide may have been added during manufacture to adjust the pH (range 4.5-7.0)

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together with the known requirement of monocytes to initiate disease in EAE 171 , this suggests an important interaction between monocytes and myelin processes in inducing demyelination