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Mayo Clinic Press
Aberrant activation of specific transcriptional programs has the capacity to greatly alter cellular state, driving oncogenesis and supporting cancer cell proliferation
3.4.2 Cancer-focused evidence In prostate cancer models (PC3, DU145), curcumin reduces the stability of the oncogenic m 6 A-modified circRNA (circ0030568) by suppressing METTL3 writer dependent methylation, which adds m 6 A marks, and down-regulating the YTHDF2 that normally binds and protects circ0030568 from degradation
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