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Despite the development of GLP-1 monoagonists, new peptides that combine the pharmacology of GLP-1 with other gut peptides increase the efficacy of these agonists while reducing their dose-related gastrointestinal side effects

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However, because retatrutide is investigational and not commercially available, any switch would currently require enrollment in a clinical trial or use of compounded/research peptide sources

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The protective effect of L-carnitine was confirmed in experiments in primary cultured mouse tubular cells