This analysis identified six primary substratesperoxiredoxin-4 (PRDX4), GRB10-interacting GYF protein 2 (GGYF2), ubiquitin-like-conjugating enzyme ATG3 (ATG3), RNA-binding protein 33 (RBM33), heterogeneous nuclear ribonucleoprotein K (HNRPK) and galactokinase (GALK1)with a greater than one log 2 fold change (log 2 FC) enrichment ( P 1, P 1), it did not reach statistical significance ( P = 0.22
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Additionally, gastrointestinal side effects of Ozempic such as nausea, vomiting or diarrhoea can lead to dehydration, particularly if accompanied by reduced food intake
These regulations were intended to limit listings to patents that directly cover the drug product or its approved uses
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