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Egr-1 gene activation: Early Growth Response gene 1 (Egr-1) functions as a master transcription switch that turns on multiple genes involved in cell growth, angiogenesis, and tissue repair

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Hypothesis 2 Smoother appetite curve GLP-1 satiety and amylin satiety are partially out-of-phase amylin signaling is more meal-bound (postprandial), GLP-1 satiety is more sustained

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