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Another drug, ES2, targets FOXO4 conserved region 3 (CR3) but has a significantly lower selectivity than FOXO4-DRI 25
Its 28-day usability window after opening is specifically designed for this use case, and using sterile water in a multi-dose context introduces a real and unnecessary contamination risk with every additional needle insertion
Researchers study it as a cytoprotective peptide, meaning they test how it protects tissue in lab models
Human trials remain scarce
This is a single rabbit study, not human evidence
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