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There are several Phase 3 trials evaluating GLP-1s for conditions, such as prediabetes, Alzheimer's disease, diabetic retinopathy and osteoarthritis of the knee (in patients with obesity)

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These adverse effects remain the most common reason for discontinuation of GLP-1 RAs therapy (46)

Activation of melanocortin signaling dopaminergic transmission in mesolimbic pathways