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GLP-1 projections from NTS to NAc and VTA promote satiation and reduce food reward, while orexinergic projection from lateral hypothalamus to NTS suppresses satiation and increases food reward ( The paraventricular thalamic nucleus (PVT) neurons receive GLP-1 innervation from NTS and express GLP-1R (Ong et al., 2017)
Counterfeit GLP-1 products may contain the wrong active ingredient, too little or too much of the active ingredient, harmful contaminants, no active ingredient at all, or entirely different medications
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its activation would lead to intracellular Na + retention, thus enhancing Na + /Ca 2+ exchange and H 2 O reabsorption (95, 96)
CBO expects the above-noted cost per user to go down as more competitors enter the market (though CBO notes that brand prices may not drop if the drugs get better as manufacturers compete on quality as well as price), more generic alternatives appear, more people use AOMs and for longer periods of time, as well as if beneficiaries who were already on AOMs prior to joining Medicare continued their treatment
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