semaglutide muscle mass loss (GLP-1) Loss: Body Composition Changes and Findings Semaglutide vs Tirzepatide: Muscle or

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Ann.Clin Psychiatry 2009;21(4):213-236

GLP-1 agonists, such as semaglutide (Ozempic), also act in the brain and have shown promising neuroprotective effects in both human trials and animal models

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Current evidence supports the long-term safety of semaglutide, with clinical trial data extending to 2 years and real-world pharmacovigilance data now exceeding 5 years for the diabetes indication