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However, this is an artifact of preclinical pharmacology methodology, i.e., extreme bolus doses and nonoral routes of administration

Neviere R, Fauvel H, Chopin C, Formstecher P, Marchetti P

doi:10.1111/j.1600-079x.2012.01029.x

NICE guidelines (NG136, NG28) recommend individualised blood pressure targets, typically below 140/90 mmHg for most people with diabetes, or below 130/80 mmHg if you have kidney, eye, or cerebrovascular disease

In some cases, compounded drugs can be helpful if there is a shortage of FDA-approved drugs or if a drug requires altering to meet someones specific needs, such as avoiding an allergen