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Chen C, Chen J, Wang Y, et al

The STEP 1 extension found that the cardiometabolic improvements seen during treatment including blood sugar, blood pressure and cholesterol largely reverted toward baseline within a year of stopping

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10 These authors found that stimulation of spinal neurokinin 1, NMDA, and non-NMDA receptors enhances spinal release of PGE2, which facilitates the release of spinal amino acids and peptides