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19 It is proved that antioxidants can reduce the expression of the receptor activator of NF-kB ligand (RANKL) and increase the expression of osteoprotegerin, 20 and osteoclastogenesis can be upregulated by increased RANKL and decreased osteoprotegerin

The adipokine leptin mediates muscle- and liver-derived IGF-1 in aged mice [PMID: 26220769] Laboratory literature summary: The adipokine leptin mediates muscle- and liver-derived IGF-1 in aged mice

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This combination is designed to provide antioxidant support and nutritional supplementation under the guidance of a healthcare professional