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DOI: 10.1056/NEJMoa2307563 Masharani U, Kroon L (2024): Pancreatic Hormones & Antidiabetic Drugs (Chapter 41)
The evidence supporting GLP-1 medications for weight loss and metabolic health is robust
Unsurprisingly, given how common gastrointestinal side effects are, the study confirmed that theres a risk of more serious issues, including gastroparesis (paralysis of the stomach) and inflammation of the colon, as well as pancreatitis
If a selective amylin agonist can hold roughly 20% at the top dose while producing placebo-like adverse-event rates at lower doses, the interesting downstream question becomes combination and sequencing, not replacement
It causes deregulation of mitochondria by increasing electron leakage from cytochromes I and IV (188, 189)
