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Doxil--the first FDA-approved nano-drug: lessons learned
Fast forward to 2024, & we have changed the protocol to oral supplementation of around 250 mg to 2000 mg daily
A 1% topical from a 100 mg vial reconstituted in 5 mL would mean roughly 0.5 mL (10 mg) blended into 1 g of finished base
Compared with placebo, those who received 9 mg of neurotrophin-3 three times per week had higher stool frequency, easier bowel movement passage, and more complete bowel movements at the end of the trial (Parkman 2003)
These neuroprotective properties have significant implications for developing treatments for neurodegenerative diseases, protecting brain tissue following injury, and understanding how growth factor signaling contributes to neuronal resilience in aging and disease contexts
