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The takeaway is simple: maintaining bone and muscle should be a central goal of any intervention in midlife and beyond
Hornigold (Cardiovascular, Renal, and Metabolism Research, MedImmune Ltd., Cambridge, UK) who contributed to the in vitro experiments described in the ESM
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To further confirm the role of NLRP3 inflammasome in fibroblast activation, three different siRNAs were designed to knock down NLRP3 expression in fibroblasts
Real-world outcomes may vary, though early observational data suggests significant weight loss is achievable in routine clinical practice with appropriate support
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