Glutathione is involved in detoxification, it binds to toxins, such as heavy metals, solvents, and pesticides, and transforms them into a form that can be excreted in urine or bile
Safety Survey of Intranasal Glutathione
[8] That is the design thesis behind retatrutides unusually large weight-loss figures and also behind its distinctive side-effect signal, discussed below
These issues might explain why some studies find no change in blood glutathione levels with supplementation
Whats more, a recent retrospective, multicenter cohort study denied higher occurrence of nonarteritic anterior ischemic optic neuropathy (NAION) in GLP-1RAs users and suggested that its potential benefits for blood glucose control and cardiovascular health likely outweigh its risks (Chou et al., 2025), despite that a few research have reported association between semaglutide prescription and a higher risk of NAION(61)