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However, since NO is freely diffusible across membranes, it is possible that the mitochondrial production of peroxynitrite may derive from extramitochondrial NO diffusing into mitochondria to react with superoxide generated by ETC
Schimidt et al., 2019
Low dietary creatine is associated with negative health outcomes in aging: A study of people over age 65 found that getting less than 1g of creatine via diet each day resulted in more than double the risk of angina (chest pain) and 2.5x the risk of liver problems
Preventing HGF nitration-dysfunction could also improve the therapeutic effects of investigational HGF drugs for various diseases including liver cirrhosis, chronic renal failure, lung fibrosis, myocardial infarction, arteriosclerosis obliterans, amyotrophic lateral sclerosis (ALS, Lou Gehrigs disease), and acute spinal cord injury 47,48,49,50,51,52,53,54,55
These last two chelators are described below
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