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Janssen, et al (2012)

In adipose models, reduced NNMT activity has been linked with smaller adipocyte size and diminished fat depots, suggesting a potential role for this inhibitor in fat mass modulation under research conditions

Study Objectives To evaluate the relationship between GLP-1 receptor agonist (GLP-1 RA) use in obese or diabetic individuals and changes in psychiatric symptoms, mental health-related QOL measures, and cognitive outcomes

Adverse effects also differ: women report higher rates of gastrointestinal intolerance (nausea, vomiting, cholelithiasis) with incretin-based therapies, likely due to estrogens effects on biliary motility [182]