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Since its inception in the early 1940s, Waddingtons concept of epigenetics took on additional meanings until encompassing the current notion of stochastic or environment-induced modifications of histone proteins or DNA without changes in the DNA sequence itself that alter the accessibility of genes to transcription factors [9]

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Long-term effects of L-carnitine on hyperammonemia and hepatic encephalopathy in patients with liver cirrhosis: a multicenter retrospective study Joji Tani a Akio Moriya b Tetsu Tomonari c Chikara Ogawa d Akemi Tsutsui e Asahiro Morishita a Teppei Sakamoto f Hiroki Tai a Rie Yano a Mai Nakahara a Kyoko Oura a Tomoko Tadokoro a Koji Fujita a Shima Mimura a Takashi Himoto g Hironori Tanaka c Ryosuke Imado d Takushi Manabe d Kei Takuma a Takuya Nagano e Koichi Takaguchi e Tetsuji Takayama c Hideki Kobara a Objective Long-term efficacy data for L-carnitine in managing blood ammonia concentration (BAC) and preventing hepatic encephalopathy recurrence remain limited

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