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Hsieh and colleagues (J Mol Med, 2017) reported that BPC 157 upregulated VEGFR2 expression and promoted receptor internalisation and downstream signalling in human umbilical vein endothelial cells, with increased tube formation in vitro and greater vessel density in a rodent hindlimb ischaemia model

This study was supported in part by the Grant-in-Aid for Scientific Research (C) (26460302 to Y.I.) and Innovative Areas (26670453 and 16K15182 to T.Y.) from Japan Society of the Promotion of Science, and grants from Japan Diabetes Foundation to Y.I

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