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Hyperandrogenism in PCOS alters the gut microbiota composition by promoting mucus-degrading bacteria (such as Ruminococcus ), while depleting butyrate-producing bacteria (like Faecalibacterium ), thereby exacerbating intestinal barrier dysfunction (38)

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NMN supplementation in mice also improved mitochondrial morphology through DRP1, and reduced ROS through antioxidant response expression 113