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Practical approaches include: sipping fluids throughout the day rather than drinking large volumes at once, choosing beverages with electrolytes when experiencing gastrointestinal symptoms, and setting reminders to drink regularly

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This study clarifies a critical variable in gerotherapeutics: the route and duration of administration do not simply alter the magnitude of a drugs efficacy

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Also, it is not known if silymarin absorbed in humans is enough to cross the blood-brain barrier and also the dosage required for optimum effect is yet to be arrived at