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-endorphin expression was mediated through autocrine activation of the IL-10 receptor- and downstream phosphorylation of STAT3 [63]
Diet tweaks that actually work To reduce nausea, GERD, and indigestion while on GLP-1s: Prefer smaller, lighter meals instead of heavy thalis or buffets Shift the plate so at least one-third to half comes from protein sources like dals, chana, rajma, soy products, paneer, curd, milk, sprouts, nuts, and seeds Choose steamed, grilled, sauted, or home-cooked dishes over deep-fried snacks and heavy gravies Limit very spicy, oily street food, especially in the first months For diarrhoea or loose motions, simple curd, buttermilk, and homemade ORS can help support gut health and hydration
Experts also recommend that excessive alcohol and toxins be avoided
A recent study investigated the effects of GLP-1R agonists in a multi-hit mouse model in which the combination of a high-fat diet and angiotensin II-induced a cardiometabolic HFpEF phenotype that resembles the human HFpEF phenotype to a large extent characterized by obesity, impaired glucose handling, and metabolic dysregulation accompanied by inflammation
