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In UK clinical settings, the recognised standard diluent for injectable medicines is Water for Injections BP (single-use, preservative-free), and the choice of diluent must always follow the licensed product's Summary of Product Characteristics (SmPC)

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caution in methylation disorders (use only under supervision) No known drug interactions with oral medications, but B12 may mask B9 (folate) deficiencycombined B-vitamin status should be assessed periodically