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Oral semaglutide has much lower bioavailability (the amount that actually reaches your bloodstream) than the injectable form, because the digestive system degrades proteins
The medication forms a depot in the fatty tissue and gradually releases into circulation over several days
In the SURMOUNT-2 study, which involved 938 adults with obesity or overweight and T2D, tirzepatide showed significant weight loss effects of 13.4% and 15.7% for the 10 and 15 mg doses, respectively, with over 80% of participants experiencing at least a 5% weight loss [92]
The gut adapts
Studies examining GLP-1 receptor agonists in women with PCOS have shown promising results: weight loss achieved with these medications has been associated with improved menstrual regularity, enhanced ovulation rates, and better metabolic parameters including insulin resistanceall factors that support fertility
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