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What Does the Preclinical Research Actually Show
It is noteworthy that exendin-4 (Ex-4), a peptide derived from the saliva of the American Gila monster, exhibits pharmacological functions similar to those of GLP-1 and is resistant to DPP-4 degradation
From 2008-2010, Sanofi-Aventis Acomplia (selective CB1 antagonist) and Abbott Laboratories Meridia (NE/5-HT reuptake inhibitor)--both also designed to suppress appetite--were pulled from the market over similar cardiac safety concerns
AGEs, advanced glycation end products
Aging 6 , 707717 (2014)
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