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reported that after 18 months of CR, the trabecular bone score at the hip decreased by 0.22%, while cortical thickness declined by 2.45%

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The article says both cause nausea, vomiting, and diarrhea, that these effects are dose-dependent and often improve with time, and that tirzepatide's dual receptor activation may make them slightly more frequent while a strength is being raised

In general, males should aim for 125 ounces (3.7 liters) of fluids per day, and females should consume 95 ounces (2.7 liters) per day, according to the National Academy of Sports Medicine

Keep a simple log noting any subjective observations