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NOX1 and NOX2 were also linked to dysregulation of redox homeostasis in SOD1 G93A mice (Marden et al., 2007)
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TRIUMPH-4: 8.8% at 9 mg, 20.9% at 12 mg
Specifically, we showed that GLP-1R activation leads to receptor segregation into flotillin-positive lipid nanodomains and that disruption of the plasma membrane architecture by cholesterol extraction with methyl--cyclodextrin (MCD) significantly reduces exendin-4-mediated receptor clustering, internalisation, and cAMP accumulation in beta cells (25)
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