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Although randomized and placebo-controlled, the study was short-term, and the patients included did not have evidence of myocardial dysfunction (mean ejection fraction, 62%)

SylvesterKGKastenbergZJMossRLEnnsGMCowanTMShawGMet al

Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-L-carnitine: Effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells

The discovery grew out of a series of eight large-scale, randomized clinical trials conducted around the world that tested these glucose-lowering drugs for heart safety

Clinical trials show that constipation occurs in approximately 6-24% of patients taking these medications, making it a recognized side effect