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Both male hemizygotes and female homozygotes with G6PD gene deficiency manifest show significantly reduced G6PD enzyme activity, while 80% of female heterozygotes show moderately reduced G6PD enzyme activity

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243,244,245,246 For example, the KD supplemented with medium-chain TG enhanced the antitumor and anti-angiogenic efficacy of chemotherapy on neuroblastoma xenografts in a CD1-nu mouse model