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121,122 Ji et al found that oral administration of TMAO significantly exacerbated demyelination in spontaneously hypertensive rats, with the underlying mechanism possibly related to TMAO-induced pyroptosis of oligodendrocytes and inflammation

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Furthermore, in the EMPA-REG OUTCOME trial, empagliflozin reduced the risk of both pump failure and sudden deaths (46)

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placebo for a 48-week period

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