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High-fat diets, for example, have been shown to increase plasma acylcarnitine levels, and this effect is partly mediated by alterations in gut microbial metabolism [177]

Amylin and GLP-1 both curb appetite, but through partly separate brain circuits amylin acts strongly via the area postrema and hindbrain, GLP-1 through its own receptor pathways

Targeting GLS1 has been shown to diminish HCC stemness by increasing ROS and inhibiting the Wnt/-catenin pathway [234]

Recent research has showed that GDF15 regulate SLC7A11 expression, and GDF15 knockdown promote erastin-induced ferroptosis by repressing SLC7A11 expression and suppressing the function of System X c (Chen L