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Preclinically extensive but structurally narrow
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[10] Evidence of increased oxidation reactions, [11] depletion of the glutathione-based antioxidant defense system, [12] and increased levels of oxygen radicals have been demonstrated in the blood and tissues of HIV-infected individuals.6 Elevated levels of hydroperoxides, [13] malondialdehyde, [14] and deficiencies of the critical antioxidant enzymes manganese superoxide dismutase, glutathione peroxidase, thioredoxin, and catalase have been demonstrated in plasma, lung lining, erythrocytes, and lymphocytes in HIV-infected individuals
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