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The ions are likely to be calcium ions (Ca 2+ ) because Ca 2+ is required for AIM/IgM binding, and binding is reduced when other divalent cations such as Mg 2+ and Zn 2+ are present instead of calcium (Supplementary Fig
Bousiou, et al
57 The herniation trajectory may also provide a way for the bacteria to infiltrate the disc, aggravate degeneration and cause Modic changes
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