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Regarding cardiovascular parameters , clinical trials have consistently observed modest increases in resting heart rate with GLP-1 receptor agonists, typically in the range of 24 beats per minute

Lancet Gastroenterol Hepatol Mantelmacher FD, Fishman S, Cohen K et al (2017) Glucose-dependent insulinotropic polypeptide receptor deficiency leads to impaired bone marrow hematopoiesis

Finally, duration of follow-up was only 1216 weeks

However, there are limitations specific to this study in addition to its retrospective nature and relatively small proportion of patients treated with GLP-1 RAs

Detailed comparison of Saxenda (liraglutide) and Zepbound (tirzepatide) for weight loss in 2026 efficacy, cost, side effects, and which to ask your doctor about