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Baroreflex activation therapy with the Barostim device in patients with heart failure with reduced ejection fraction: a patient level meta-analysis of randomized controlled trials

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Rather than writing off histamine as a bystander in common allergic reactions, we must consider histamine as a primary agent for various destabilizing effects in the body and a considerable source of systemic stress

GEP44 was developed based on extensive structureactivity relationship studies and earlier preliminary in vivo studies that demonstrated its greater efficacy at reducing both food intake and body weight compared to the agonist peptide, Ex-4, without triggering gastrointestinal distress (as assessed by kaolin intake and behavioral scoring as a proxy for nausea in rats and direct evidence of emesis in shrews) 16

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