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Individuals 65 years and older with comorbidities, are more susceptible to become infected with SARS-CoV-2 and become critically ill and are more prone to develop ARDS and require mechanical ventilation, having a high 28-day mortality rate (Yang X

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Furthermore, it has emerged that supporting or inducing mitochondrial bioenergetics, stress responses, mitophagy, and other adaptation mechanisms is critical to mediate some of the health or longevity benefits observed in studies using NAD + modulation strategies

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