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Reports from the FDA have linked medications like exenatide to altered kidney function, particularly in patients with additional risk factors such as nephrotoxic drugs and hypertension
Duan Y, Dai H, An Y, Cheng L, Shi L, Lv Y, et al
Unlike folate receptor, which marks aggressive but differentiated tumor cells, CD44 enrichment identifies subpopulations with self-renewal capacity, enhanced invasiveness and intrinsic resistance to conventional chemotherapy, making it an especially compelling target for nanocarrier-mediated delivery [135, 136]
While clinicians should not limit their usage due to cancer concerns, they must maintain a thorough surveillance for possible adverse outcomes
A preclinical study showed that combining the MCT1 inhibitor AZD3965 with anti-PD-1 therapy reduces lactate release into the TME, enhancing tumor immune efficacy (48)
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