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Those effects go away after the first week or two
However, limited long-term human lactation studies exist for either compound, which explains why many manufacturers note breastfeeding as a consideration rather than an absolute contraindication
GH Secretagogue Comparison Compound Class Receptor FDA Status Ipamorelin GHRP (ghrelin mimetic) GHS-R1a Not approved CJC-1295 GHRH analog GHRH-R Not approved Sermorelin GHRH analog GHRH-R Previously approved (Geref, discontinued) Tesamorelin GHRH analog GHRH-R FDA approved (Egrifta) GHRP-2 GHRP (ghrelin mimetic) GHS-R1a Not approved GHRP-6 GHRP (ghrelin mimetic) GHS-R1a Not approved Selectivity Profile: The Key Research Differentiator What makes Ipamorelin stand out among GHRPs is its endocrine selectivity
These hormones promote feelings of fullness after eating, insulin secretion and production, and help reduce hunger to avoid overeating
A 2024 survey of 340 obesity medicine specialists (Fitch et al., Obesity Science & Practice ) found that 68% restart at 2.5 mg, 24% start at 5 mg, and 8% individualize based on patient history
