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Oxidative stress in the RPE, induced by ROS such as hydrogen peroxide, is hypothesized to be an important driving force in the progression of this disease [16]

As COPD remains a major public health concern due to lack of effective therapeutic strategies, we sought to use computational methods to identify compounds that might modulate molecular processes associated with emphysema pathogenesis

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In ALS, alterations in SIRT1 levels have been determined in postmortem tissues from patients (Krner et al., 2013) and in mouse models of ALS (Han et al., 2012)