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Reinforce education on potential benefits (weight loss, lower insulin requirements) and risks (hypoglycaemia, ketosis/DKA)
A whole cottage industry is springing up to test these research compounds
In contrast, a pooled analysis of clinical trials reporting separate CV events rates in patients with T2D and CKD did not find GLP1-RA to be associated with a reduction in composite CV event rates [76]
This led to upregulation of cytoprotective genes (e.g., HO-1 , glutathione S-transferases) and mitigation of oxidative stress and inflammation in the liver
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