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Subtle differences with respect to interactions with the ECLsspecifically, the TM 6-ECL3-TM7/TM1have led to biased agonism (i.e., selective agonism of the cAMP signaling pathway)
In the case of concussion or severe TBI, the course of recovery generally follows the same pattern: an initial period of impaired brain function, a period of improvement, and a period where the mental functioning stabilizes without significant additional deterioration or improvement
Duro-Castano A, England RM, Razola D, Romero E, Oteo-Vives M, Morcillo MA, et al
10.4103/2278-0513.148915 184 MohibbullahM.HaqueM
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